Multifocal recurrent conjunctival melanoma with diffuse primary acquired melanosis
نویسندگان
چکیده
منابع مشابه
Management of Primary Acquired Melanosis, Nevus, and Conjunctival Melanoma.
BACKGROUND The management of conjunctival melanoma is difficult because of the rarity of the disease, confusing terminology, high rates of local tumor recurrence, controversies regarding treatment, a poor evidence base, unreliable prognostication, and significant mortality rates. METHODS The medical literature was reviewed, focusing on treatment and management options for conjunctival melanom...
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AIM To evaluate the efficacy of amniotic membrane transplantation (AMT) for the management of conjunctival malignant melanoma and primary acquired melanosis (PAM) with atypia. METHODS Four consecutive patients with histologically proved invasive, primary conjunctival malignant melanoma were treated with wide surgical excision and AMT. Amniotic membrane grafts were harvested and processed unde...
متن کاملProgression of conjunctival primary acquired melanosis (PAM) to widely spreaded malignant melanoma.
Primary acquired melanosis (PAM) is an acquired pigmentation of the conjunctival epithelium, a preinvasive pigmented lesion. When it is associated with cellular atypia it can lead to the developement of melanoma. We report a case report of malignant melanoma of the conjuntiva, which arrised from the conjuntival PAM. The disease was too extensive for ocular conservation, therefore exenteration w...
متن کاملCell growth and p53 expression in primary acquired melanosis and conjunctival melanoma.
AIMS To evaluate cell growth and the pattern of p53 suppressor gene expression in atypical primary acquired melanosis (PAM) and in recurrent conjunctival melanoma. METHODS Eighteen specimens of PAM with atypia and 24 specimens, comprising early and late lesions, from 12 patients with conjunctival melanoma were stained for the proliferating cell nuclear antigen using the PC10 antibody, and for...
متن کاملMultifocal amelanotic conjunctival melanoma
Clinical and histopathological features of four cases of multifocal amelanotic malignant melanoma of the conjunctiva in association with 'acquired melanosis sine pigmento' are reported. The absence ofconjunctival pigmentation in this extremely rare combination of lesions prevented early diagnosis and clinical monitoring. As a result orbital exenteration was required in three cases. This multice...
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ژورنال
عنوان ژورنال: Indian Journal of Pathology and Microbiology
سال: 2019
ISSN: 0377-4929
DOI: 10.4103/ijpm.ijpm_15_18